Chronic Hepatic Viral Infection Could be a Protective Factor for ...

Yang Zeng, Xiao-Wen He, Xiao-Sheng He, Xiao-Jian Wu, Jin-Ping Ma, Jian-Pin Wangand Pin Lan

DOI 10.5754/hge12564

2013; 60(121): Ahead of print.

KEY WORDS: Hepatic viral infection; Colorectal cancer; Liver metastases; Survival.

ABSTRACT

Background/Aims: We tested the hypothesis that chronic hepatic virus infection could reduce the occurrence of colorectal cancer liver metastases (CLM) and investigated CLM patients? survival prolonged in positive viral infection. Methodology: 2868 colorectal cancer patients were divided into positive-infection and non-infection groups. Clinical variables, incidence of liver metastases and survival between the groups were respectively analyzed. Results: The incidence of liver metastases in the positive group was much lower than in the control group, but other type distant metastasis was similar in the two groups. Infected group 5-year overall survival (OS) was better than the negative group. Meanwhile, CLM patients in the former group showed longer survival time than the control group (26 months vs. 20 months, p<0.001). Conclusions: Chronic hepatic viral infection could reduce the occurrence of CLM and improves the survival time of colorectal cancer. It could be a protective factor for CLM patients.

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Source: https://www.hepato-gastroenterology.org/?p=5701

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